This lecture addresses architecture as the construction of possible worlds based on genetic systems. As such it proposes a computational monadology or philosophical genetics as the theoretical foundation for genetic architecture. It situates this approach within the context of the idea of world-making that is increasingly dependent on the capitalization of the logic of evolution. Karl S. Chu is principal of the architectural studio METAXY. He is the Director of the Institute for Genetic Architecture at the Graduate School of Architecture, Planning and Preservation, Columbia University, New York, where he teaches advanced architectural studios. He is a Co-director of the Biodigital Architecture Program at ESARQ, Universitat Internacional de Catalunya, Barcelona. He also teaches at the School of Architecture, Pratt Institute, Brooklyn. He is involved in the research and development of genetic architecture as well as theoretical and philosophical inquiry into the ontology of genetic systems. He has taught, lectured, published and exhibited internationally. Currently, he is working on three books: Toward Genetic Architecture (student works from the GSAPP), Planetary Automata, and a theoretical inquiry titled Ontology of Genetic Architecture. NB: Cuts out abruptly.